EU grants and achievements

Development and clinical testing of the medical device for vagus nerve stimulation in the treatment of Alzheimer's disease - VGuard.
Project No.: RPLD.01.02.02-10-0067/17-00.

Project co-financed by Regional Operational Programme for Lodzkie Voivodeship for 2014 – 2020, Priority I: Research, development and commercialization of knowledge; Activity I.2: Investments of enterprises in research and innovation; Sub-activity I.2.2: R&D projects of enterprises, Competition no.: RPLD.01.02.02-10-0067/17-00.

The main goal of the project is to create medical device dedicated for older population with cognitive disorders (especially with Alzheimer’s disease). The role of the device is to stimulate (non-invasively) the brain . This intervention will modify activity of neuron networks in specific brain areas. Mild electrostimulation (on low parameters) influences neurons activity mainly in the hippocampal formation. This structure is responsible for learning, memory consolidation and spatial navigation. Hence that, the main goal of the device is to help older population with cognitive disfunction to boost memory. Device is dedicated for patients with mild cognitive impairment (MCI), specially for patients with Alzheimer’s disease or Dementia above 60 years old. Cogniguard treatment will be a pioneering solution on a global scale, introducing a new method of therapy delaying the development or reducing symptoms of the disease. What is important VGuard device will be working in wireless bluetooth connection to personal mobile devices, what allow to save the stimulation parameters and quickly facilitate the personalization of the therapy.

Publications


  • Broncel A., Bocian R., Kłos-Wojtczak P., Konopacki J. 2021, Noradrenergic Profile of Hippocampal Formation Theta Rhythm in Anaesthetized Rats
  • Broncel A. ,Bocian R. , Kłos-Wojtczak P. , Kulbat-Warycha K. , Konopacki J. 2019, Vagal nerve stimulation as a promising tool in the improvement of cognitive T disorders.
  • Broncel A., Bocian R., Kłos-Wojtczak P., Konopacki J. 2018. Medial septal cholinergic mediation of hippocampal theta rhythm induced by vagal nerve stimulation. Plos One. 5;13(11).
  • Broncel A., Bocian R., Kłos-Wojtczak P., Konopacki J. 2018. Some technical issues of vagal nerve stimulation. An approach using a hippocampal formation theta rhythm. Brain Res Bull. 140:402-410.
  • Broncel A., Bocian R., Kłos-Wojtczak P., Konopacki J. 2017. Vagus nerve stimulation produces a hippocampal formation theta rhythm in anesthetized rats. Brain Res. 1675:41-50.
  • Calzato L.S., Ritter S.M., Steenbergen L. 2018. Transcutaneous vagus nerve stimulation (tVNS) enhances divergent thinking. Neuropsychologia 111 (2018) 72–76.
  • Jongkees B.J. Immink M.A., Finisguerra A., Colzato L.S. 2018.Transcutaneous Vagus Nerve Stimulation (tVNS) Enhances Response Selection During Sequential Action. Front Psychol. 2018; 9: 1159.
  • Sellaro R, de Gelder B, Finisguerra A, Colzato LS. 2018. Transcutaneous vagus nerve stimulation (tVNS) enhances recognition of emotions in faces but not bodies. Cortex, Volume 99, February 2018, Pages 213-223.
  • Jacobs HI, Riphagen JM, Razat CM, Wiese S, Sack AT., 2015. Transcutaneous vagus nerve stimulation boosts associative memory in older individuals. Neurobiol Aging. 2015 May;36(5):1860-7.
  • Lorenza S. Colzato, Simone M. Ritter, Laura Steenbergen. 2018. Transcutaneous vagus nerve stimulation (tVNS) enhances divergent thinking. Neuropsychologia 111 (2018) 72–76.
  • Clark, K.B., Naritoku, D.K., Smith, D.C., Browning, R.A., Jensen, R.A., 1999. Enhanced recognition memory following vagus nerve stimulation in human subjects. Nat.Neurosci. 2, 94–98.
  • Sjögren MJ., Hellström PT., Jonsson MA., Runnerstam M., Silander HC., Ben-Menachem E. 2002. Cogniction-enhancing effect of vagus nerve stimulation in patients with Alzheimer’s disease: a pilot study. J Clin Psychiatry. 63(11):972-80.
  • Merrill CA., Johnsson MA., Minthon L., Ejnell H., C-son Silander H., Blennow K., Karlsson M., Nordlund A., Rolstad S., Warkentin S., Ben-Menachem E., Sjögren MJ. Vagus nerve stimulation in patients with Alzheimer’s disease: Additional follow-up results of a pilot study through 1 year. J Clin Psychiatry. 67(8):1171-8.